Wine holds an interesting place in the history of Microsoft, which in the past opposed the software but more recently held up Wine as an example of the importance of open APIs.
SEE: Windows 10 toolbar: Here's how Microsoft is adding news, weather and traffic As opposed to running a VM or emulator, Wine focuses on Windows application protocol interface (API) calls and translating them to Portable Operating System Interface (POSIX) calls. Wine (Wine is Not an Emulator) is for getting Windows apps and games to run on Linux and Unix-like systems, including macOS.